Take another look at the original sentence:

Ryan is highly allergic to cats, he requires at least twenty god-bless-yous every time he visits Mariko and her seven Siamese.

You chose to fix it the correct way:

Ryan is highly allergic to cats, so he requires at least twenty god-bless-yous every time he visits Mariko and her seven Siamese.

Ryan is highly allergic to cats is a main clause. He requires at least twenty god-bless-yous is the second main clause. You are always correct when you use a comma and a coordinating conjunction like so between the two main clauses that create the comma splice.

Go to the next sentence.

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